Most health impacts will be adverse and will occur via direct exposures (e.g., heat waves, extreme weather events) and less direct influences arising from disruptions to environmental, ecological, and social systems.
The different disorders probably arise from disruption of neurotransmission in specific brain regions: the cortex in the case of migraine, the thalamus in the case of absence epilepsy and the cerebellum in the case of ataxia.
We illustrate these insights by describing the development of a design-reuse system that maximizes the benefits of rationale capture and information retrieval whilst minimising the costs to the designer that might arise from disruption to natural design work.
These necrotic areas may arise from disruption of bile acid flow, since bile acids are strong detergents and buildup in the liver can lead to necrosis, fibrosis and cirrhosis [6].
Equally important, the deficiencies only rarely arose from disruption of IF-mediated absorption, such as pernicious anemia (8, 10, 14).
(17) It is unclear, however, whether this loss of activity arises from disruption of protein contact(s) to the bulged-G nucleobase or from indirect effects.
This condition arises from disruption of the lymphatic system in coping with the axillary approach for staging or control of the disease [ 8, 14].
Therefore, the non-nuclear-localization may arise from disruption of functionality of HLH-30b/c::GFP fusion proteins and, as the cellular distribution is indistinguishable, this expression does not provide support for transcripts d/e.
In Neurospora crassa, an insertional mutant that constitutively initiated, but failed to complete, conidial development arose from disruption of nrc-2, a gene encoding a serine-threonine protein kinase [ 48].
Although these syndromes are all associated with SDH deficiency, few genotype phenotype relationships have yet been established, and indeed it is remarkable that such divergent phenotypes can arise from disruption of a common molecular pathway.
