Sentence examples for arising deleterious from inspiring English sources

Purging can prevent fitness loss only if all newly arising deleterious mutations are removed from a lineage.

Using this approach, we estimate that the average intensity of selection on newly arising deleterious nonsynonymous mutations in the two species is higher in D. simulans (table 4).

We use the approach of Keightley and Eyre-Walker (2007) to jointly estimate the distribution of fitness effects (DFEs) of newly arising deleterious nonsynonymous mutations and parameters of an instantaneous population size change model.

Similar to other studies that previously proposed to estimate the distribution of arising deleterious mutations (Keightley 1998; Eyre-Walker and Keightley 2007), we have assumed a Gamma distribution because it can have a wide range of shapes.

Limited recombination among targets of selection is also predicted to lead to reduced diversity, whether by selective sweeps that wipe out standing variation (Maynard Smith and Haigh 1974; Gillespie 2000) or by background selection against continually arising deleterious mutations that prevent diversity from accumulating in the first place (Charlesworth et al. 1993; McVean and Charlesworth 2000).

Conversely, if the influx of deleterious mutations were to overwhelm the purging process by preventing the production of offspring free of newly arisen deleterious mutations, then selfing organisms would be at risk of fixing increasing numbers of deleterious mutations and become subject to a mutation meltdown [21], [22].

These aspects of genome erosion are explained by a Muller's ratchet process that affects endosymbionts because of their small population size and isolation within host cells where they lose access to external sources of DNA to repair newly arisen deleterious mutations [ 9].

Interestingly, newly arising strongly deleterious (2 N e s ≈ 19 ) mutations that are destined for ultimate fixation arrive there nearly three times faster on average than new neutral mutations (fig. 4, left panel).

Hence selection of mates based on indirect fitness benefits can be maintained perhaps not because of the presence of "good" genes, but because females are attempting to avoid "bad" genes arising from deleterious mutations as expressed in condition-dependent secondary sexual characters.

By the same token, new interfaces arise without deleterious structural consequences, which increases the functional repertoire of IDPs.

European ancestry individuals have been reported to have an excess of recently arisen potentially deleterious variants in disease genes.