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As for the ARF, it usually attracts more headlines, in the western media at least, for the skits the leaders perform at their evening party than for any of their more substantive discussions.
Why am I reminded of I Dream Of Wires (arf!, it's still a good one) when I hear The Joy Of Concrete?
The mortality rate in the admissions complicated with ARF was 54.2% and in those without ARF it was only 16% (odds ratio for death, 6.6).
The average highest creatinine in this group was 3.3 ± 1.3 mg/dL, whereas in those without ARF it was 1.6 ± 0.7 mg/dL (P < 0.0001).
Although the targets of Exo1 and Exo2 remain unknown, Exo1 has been shown not to interfere with GEF-stimulated GDP/GTP exchange on ARF; it somehow interferes with the ARF-dependent GTP hydrolysis step [ 17].
Renal failure was usually associated with at least another organ dysfunction as demonstrated by mean SOFA at day 1 (9.3 ± 4.5) whereas without ARF it was 3.7 ± 3 (P < 0.001).
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