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Importantly the Areal study included the chicken TLR5 gene sequence (NM_001024586.1) in the analysis of TLR5 (see Table S5 of [ 6]).
For the same 6-year period, a geographical (areal) study found an SIR of 2.2 (1.0, 4.4) for the 0 4 year age group and <5 km area, while for 1990 2007 the SIR was 1.4 (0.8, 2.3) (Sermage-Faure et al, 2012).
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Whilst our findings largely support those of their study Areal et al used a reduced group of animals to identify positive selection.
In spite of the criticisms of areal or ecological studies, it has to be recognised that case control studies involve appreciable difficulties in the selection of suitable controls.
At the areal level, previous studies of PCBs and ambient carbon monoxide show that birth weight is associated with distance from the source of the pollutants or the site of their measurement (Baibergenova et al. 2003; Ritz and Yu 1999), suggesting that geographic location can be used to approximate level of exposure.
While this methodology usually enables the unambiguous detection of direct inter-areal connections, tracing studies are subject to technical caveats, which affect especially older results.
This paper presents a Spearman's correlation study of areal surface texture parameters on some typical machined surfaces.
In this PSHA, both fault lines and areal SSZs, including the study areas of Thailand, were gridded equally as 0.25° × 0.25° grid cells.
The study site areal extent is approximately 84 km2 and is situated at about 5 km west of Enugu city, southeastern Nigeria.
Like all such broad generalisations in "areal linguistics" (the comparative study of languages within a given region), this one begs a number of relevant questions; but it will serve as a starting point for the present discussion.
However, it has been always a problem in biodiversity studies about what is a reliable description of local species richness because of the scale effect (here it is more about a range and areal extent in a study).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com