Sentence examples for area of linkage from inspiring English sources

This showed SERPINE2 to be within the area of linkage (chromosome 2q33) and to be highly expressed in the lung, making it a logical candidate gene.

To proceed from an area of linkage to a disease-associated mutation requires knowledge of the specific genes that exist in that chromosomal region.

Given the large area of linkage disequilibrium surrounding these SNPs, further fine-mapping and functional characterisation will have to be performed.

Using this approach, we were able to identify several common variants in an area of linkage disequilibrium on chromosome 12q13 that were associated with total body BMD as measured at 9.9 years.

Several SNPs showed evidence of association in both the ALSPAC discovery set and the Australian extremes study (see Supplementary Material, Table S5), including SNPs in a large area of linkage disequilibrium (∼500 kb) on chromosome 12 which contained the strongest statistical evidence of association in both scans (P <.001 in both scans, Supplementary Material, Table S5, Fig.  1 and Table  2).

It was identified as a potential candidate gene for COPD by integration of an area of linkage on chromosome 2q33 from the Boston early-onset COPD cohort [ 45, 46] with knowledge of gene expression during murine lung development and from human lung microarray datasets [ 47].

Although there are a few areas of linkage, the relationship between the two is not strong.

Surprisingly, we also showed that the Mendelian inheritance involves a broad region of LGIV with several distinct areas of linkage.

Unlike previous studies, which have identified mutations in humans because of similarities in phenotype with the null mouse, our systematic approach guided by areas of linkage has allowed us to screen all transcription factor genes independently of clinical features.

This option is used when testing for associations in an area of known linkage (the null hypothesis assumes no association but linkage) with multiple affected siblings in a family or when multiple nuclear families in a pedigree are considered.

The findings revealed a need for training of a number of groups including data custodians and researchers, however, training for HREC members in the area of data linkage was identified as a priority by a number of the data linkage units consulted [ 10].