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With the progression of the disease the area of alteration might be expanded.
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Results: Gross inspection showed a small circumferential area of tissue alteration localized to the posterior annulus but not extending to the endplates.
Vision disturbances often consist of a scintillating scotoma (an area of partial alteration in the field of vision which flickers and may interfere with a person's ability to read or drive).
Systematic research that integrates both mechanistic and clinical research is desirable when investigating the complex area of pharmacokinetic alterations during ECMO.
Systematic research that integrates both mechanistic and clinical research is necessary when investigating the complex area of pharmacokinetic alterations during ECMO.
On imaging, these lesions may show imaging features suggestive of a brain tumor or abscess displaying solitary or multiple focal areas of signal alteration with an irregular peripheral enhancement and a mild to moderate mass effect on adjacent brain structures.
Although molecular analyses of peritumoral tissues are providing evidence for breast field effects (the presence of larger areas of molecular alteration surrounding histologically confirmed breast cancer foci), epidemiological data inter-relating breast cancer risk factors, breast cancer subtypes and characteristics of benign tissues surrounding cancers are limited.
Since the WEE1 genomic locus is not placed in an area of chromosomal number alteration (CNA) in any of our glioma specimens we ruled out that the levels of WEE1 gene expression are simply explained by alterations of gene copy numbers (data not shown).
Urban sprawl has led over wide areas to alteration and fragmentation of so many ecosystem types that it becomes essential to consider biodiversity conservation in urban planning.
As the venous system is an important capacitance area of the body, alterations in its capacity can cause large changes in venous return and cardiac preload.
In spite of being a relatively new area of study, epigenetic alterations have enabled the understanding of the differences present in the gene expression profiles in different diseases, including carcinogenic processes.
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