The phrase "are well known to function" is correct and usable in written English.
It can be used when discussing something that is widely recognized for its effectiveness or operational capability.
Example: "These methods are well known to function effectively in various applications."
Alternatives: "are widely recognized to operate" or "are commonly understood to work".
Heat shock factors (Hsfs) are well known to function in the regulation of stress-inducible genes (e.g., Hsp) by recognizing a conserved binding motif (heat shock element [HSE]: three inverted repeats of nGAAn units [ 28, 29]).
Transporters are well known to function either as passive transport systems, carrying molecules down their concentration gradient, or as active transport systems, using energy to carry molecules uphill against their concentration gradient.
GABA (γ-aminobutyric acid) is well known to function as an inhibitory neurotransmitter in the mammalian CNS (central nervous system).
Protein phosphorylation, which is well known to function in recruitment of the ubiquitination machinery to the substrate [ 12], may also act directly to regulate the activity of distinct ubiquitin ligases.
Ubiquitin, primarily mono-ubiquitin, is well known to function as an internalization signal for eukaryotic plasma membrane proteins (Mukhopadhyay and Riezman, 2007), but this is the first example for a bacterial virulence protein.
Respiratory tract infection and inflammation are well known to affect respiratory function, particularly in exacerbations of asthma and COPD, but there have been few studies into the action of infection on cough.
Elevated stress levels, associated with stressful events such as exam periods, are well known to compromise immune functioning, and increase rates of infectious diseases in students [54], [55].
Age and education are well known to affect neurocognitive functioning (Anger 2000; Leckliter and Matarrazo 1989; Zhou et al. 2002).
Calcineurin phosphatase inhibitors remain the mainstay of many antirejection regimens, and the agents are well known to progressively impair renal function.
Intestinal commensal bacteria are well known to impact on the organization and function of the immune system [38], and we observed that LPS could impart PLN-DC with an IgA promoting phenotype similar to that of PP-DC.
These findings are consistent with H2O2 effects being mediated through the production of RLS, which are well known to modify proteins and change protein function.
