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The phrase "are very substantial" is correct and usable in written English.
It can be used to describe something that is significant or considerable in size, amount, or importance.
Example: "The findings of the research are very substantial, indicating a strong correlation between the variables studied."
Alternatives: "are quite significant" or "are highly considerable."
Dictionary
Exact(27)
But there are very substantial differences between the two groups.
"Our client base is looking at things that are very substantial.
"There are very substantial differences between the Holocaust and other genocides," he says.
"We do see that there are very substantial reasons for people to diversify their assets, and to consider places such as Switzerland for part of that".
"There are very substantial constituencies that are watching very closely on these issues," said Representative George Miller, Democrat of California, who is on the Energy and Commerce Committee.
He blamed police for too often greeting complainants with scepticism and inertia, and said officers "must absolutely accept the victim's version of events unless there are very substantial reasons to do otherwise".
Similar(31)
He's very substantial".
They're very substantial.
The evidence is very substantial.
"The remorse here is very substantial".
"There have been very substantial gains at this point.
More suggestions(17)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com