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Discover LudwigThe phrase "are very different indeed" is correct and usable in written English.
It can be used to emphasize a significant difference between two or more subjects.
Example: "The two cultures are very different indeed, with distinct traditions and values that set them apart."
Alternatives: "are truly distinct" or "are remarkably different".
Exact(8)
On arrival, she thinks nothing has changed - but soon it becomes apparent that things are very different indeed.
Both buildings are very different indeed from Piano's first art gallery, the flamboyant Pompidou Centre in Paris, designed with Rice and Richard Rogers soon after the demonstrations and riots of 1968, and completed in 1977.
But, ah, things are very different indeed in the fraternity of professional chefs and cookbook authors, where jealousies and passions are as plentiful as stuffed artichokes, and charges of plagiarism of recipes at times seem almost pandemic.
But some people, synaesthetes like Wannerton, are very different indeed.
But fast forward to today and things are very different indeed.
The phenomenal character (the 'what it's like-ness') of actually seeing a car turn a corner, and remembering (via recollected visual images) seeing an otherwise similar car turn a corner are very different indeed.
Similar(52)
The biggest difference, aside from language, which is very different indeed, is the money.
Outside, it is very different indeed.
But with Tacoma, you sense that the mystery – and the solution – will be very different indeed.
Then the future came – and turned out to be very different indeed.
But the latest issue of the travel magazine is very different indeed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com