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The phrase "are vast differences in" is correct and usable in written English.
It can be used when discussing the existence of significant variations or disparities between two or more subjects.
Example: "There are vast differences in the educational systems of various countries, affecting student outcomes and opportunities."
Alternatives: "exist significant disparities in" or "show considerable variations in".
Exact(18)
2) From the extreme variety of neurons that express GAL4 in the different Drosophila lines (there are vast differences in both total cell numbers and anatomical distributions), it is remarkable that these lines express such specific behavioral activations when heated.
Besides, there are vast differences in cell ploidy and genetic characteristics of different Lilium genotypes.
There are vast differences in development and economic well-being in the country's 8 parts.
There are vast differences in the political worldview between Mr. Paxon, 46, and Mr. Strauss, 81, his boss.
That there are vast differences in people's innate abilities at birth is not news either, and our knowledge-based economy exacerbates the financial results of those differences.
There are vast differences in the quality of their writing, but they share an ability to spin addictive yarns about people in peril - who are usually saved by a familiar, flawed hero.
Similar(42)
Different carcinogens produce different levels of risk, and for a given carcinogen there may be vast differences in the risks incurred by different people exposed under different circumstances.
Even though these properties are quite similar between the respective HBDs, there can be vast differences in their effectiveness against different bacterial strains and in their modes of action.
Since there were vast differences in the absolute concentrations among different metabolites, we standardised the concentration by using the Z-score for comparability between different metabolites for their biological relevance and used them in subsequent analyses.
Yet there have been vast differences in student performance on standardized tests at charter schools in Chicago, according to state testing data released last year.
By contrast, for measures of accuracy, there appear to be vast differences in learning techniques.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com