The phrase "are unfortunately significant" is correct and usable in written English.
It can be used to express that something has importance or relevance, but it is regrettable or undesirable.
Example: "The findings of the study are unfortunately significant, indicating a rise in pollution levels that could harm the environment."
Alternatives: "are regrettably important" or "are sadly noteworthy".
The formations, although fascinating and significant, are unfortunately not conclusive pieces of evidence that life has existed on Mars.
The scale-up of these processes is often problematic, which can be related to the intrinsic complexities of these flows which are unfortunately not yet fully understood despite significant efforts made in both academic and industrial research laboratories.
"It's unfortunately not statistically significant yet," Gregory said.
Thus, The Favourite's power structure is, unfortunately, unusual and significant (both cinematically and in the general context of historical accounts of the British monarchy), not least because director Lanthimos has enabled the film's woman-centrism to move through its every second.
Body mass measurements of symptomatic runners who presented to the medical tent were, unfortunately, not obtained due to significant clinical symptomatology that precluded ambulation to designated weighing stations.
Victim blaming is unfortunately common and is one of the most significant barriers to justice and offender accountability".
I was, unfortunately, right".
Unfortunately, significant artifacts were present due to light channeling within the plastic (see homogeneous phantom data represented by blue dots in Fig. 4(f) ).
Unfortunately, significant glomerular lesions can be present in normoalbuminuric patients [ 1].
"These findings are significant but unfortunately provide no in vivo data showing tumor progression in animals due to loss of mitochondrial function by TCDD," says Keshav K. Singh, a cancer geneticist at Roswell Park Cancer Institute in Buffalo, New York.
