Sentence examples for are unable to activate from inspiring English sources
Our findings obtained using two different anti-AR antibodies as well as the inhibition of cell motility by the anti-androgen Casodex reveal that HT1080 cells harbor low levels of classical AR that mediate androgen-induced migration but are unable to activate gene transcription, as assessed by gene reporter assay.
In contrast, tumor cells are unable to activate this protective response due to uncontrolled activation of growth pathways by oncogenic mutations.
In keeping with this observation, ERF.D.1 and ERF.D.2 are lacking the acidic activator domain and accordingly are unable to activate the synthetic GCC box promoter.
Furthermore, the possible role of MAPK in MPF activation in mammalian oocytes was ruled out by the observation that oocytes derived from mos-knockout mice, which are unable to activate MAPK, display a normal pattern of MPF activation during germinal vesicle breakdown and Pb1 emission [45].
beta(1 -ARs with PKA phosphorylation sites mutated to alanines are unable to activate ERK.
The protective effect presumably occurs because class II-deficient endothelial cells are unable to activate allogeneic CD4 + T cells, depriving the CD8 + T cells of "help" required for differentiation into cytotoxic T cells, which mediate graft cell destruction.
RSV was unable to activate PRDIII luciferase reporter activity in the cells transfected with empty vector or in those reconstituted with IKKγΔ (Figure 5D).
Furthermore, BPA was unable to induce functional foci in the nuclei and is consistent with the transient transfection study that BPA is unable to activate AR.
Unlike E2F1, E2F3 is unable to activate mTORC1, suggesting that growth activity could be restricted to individual E2F members.
As expected, MAVS was unable to activate NF-κB-driven luciferase reporter activity in IKKγ−/− MEFs, and mediated a 4-fold increase in IKKγ-WT transfectants (Figure 3B).
Trypsin, copper acetate and sodium dodecyl sulphate were unable to activate PPO, suggesting that the enzyme was in the active form.
