The phrase "are two major drawbacks" is correct and usable in written English.
It can be used when discussing the negative aspects or disadvantages of a particular subject or situation.
Example: "While the new software has many benefits, there are two major drawbacks that users should be aware of."
Alternatives: "present two significant downsides" or "have two key disadvantages".
There are two major drawbacks to such a validation standard.
There are two major drawbacks of this method.
Precious studies show that formation damage and injectivity decline are two major drawbacks associated with PWRI performance in hydrocarbon aquifer.
There are two major drawbacks found in BEB that cause the network degradation as discussed in [17].
Time of the reconstruction and high radiation dose imposed on patients are two major drawbacks in computed tomography.
However, the narrow-spectra absorption range and serious recombination reactions at electrode/electrolyte interfaces are two major drawbacks for high-performance solar cells.
There is one major drawback to using Wi-Fi to connect a player and speaker.
There is one major drawback: as is so often the case at the Brooklyn Museum, the works suffer from an egregious exhibition design, this one punctuated with red and black walls and large, screenlike dividers made of blown-up details of some of the drawings.
Although the already reported methods are successful, they have two major drawbacks: the time required for the complete formation of PEG-functionalized AgNPs can reach several hours, and the methodology is quite complex in most of the cases.
While these methods are very efficient, they have two major drawbacks.
For the conventional SONOS memory, erase saturation and vertical stored charge migration [79, 80] are the two major drawbacks; the most challenging tasks are how to maintain an acceptable charge capability of the discrete storage nodes and how to fabricate nanocrystals with constant size, high density, and uniform distributions [81].
