Adding to the complexity of potential mechanisms is the severe neurodegeneration in mice with mutations in both Siat9 and Galgt, which are totally deficient in the common brain gangliosides (R.L.P., unpublished data).
Unfortunately, since scid/mdx, nu/nu/mdx mice, or CD4 depleted mdx mice are totally deficient in Th cells, these models are unable to reveal the roles of their different polarizations (Th1, Th2, Th17, and Tregs) which probably play nonredundant and even opposite roles in the progression of fibrosis [ 64].
Strikingly, however, rA75/17red Hko/Hcomp was totally deficient in cell-to-cell transmission, since viral infection remained restricted to the initially infected cells (Fig. 8a d).
In addition, cells from MyD88-deficient mice are totally unresponsive to peptidoglycan, lipoprotein, CpG DNA, and imidazoquinolines in terms of cytokine production [ 12, 27, 28] (Fig. 3).
Expression analyses of MMR and MGMT in MB revealed that all patient specimens (n=74; expression array, n=61; immunostaining, n=13) are most likely MMR proficient, whereas some tumours had low MGMT expression levels (according to expression array) or were totally MGMT deficient (3 out of 13 according to immunohistochemistry).
Few situations are totally good or totally bad.
Not that I could have, being completely deficient in Chinese.
For each complex, fibers with strong red (porin) staining but no green staining were considered totally deficient, fibers with patchy green and red staining were considered partially deficient, while fibers lacking both red and green staining were considered to show mitochondrial hypodensity.
For each complex, fibers with strong red (porin) staining but no green staining were considered totally deficient (i.e. homoplasmic for mutant mitochondria), fibers with a patchy green and red staining were considered partially deficient (i.e. heteroplasmic for mutant mitochondria), while fibers lacking both red and green staining were considered mitochondrially hypodense.
So although the morphology of the oocytes is totally normal, these Ago2-deficient oocytes already have a severe defect of spindle formation and chromosome arrangement, which is similar to the defect observed with the Dicer knockout oocytes [ 6].
"The report also reinforces the conclusion that the global capital standards applied before the crisis were severely deficient and liquidity regulation was totally inadequate.
