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The phrase "are therefore substantial" is correct and usable in written English.
It can be used to indicate that something is significant or considerable as a result of previous statements or evidence.
Example: "The findings from the research are therefore substantial, suggesting a need for further investigation."
Alternatives: "are thus significant" or "are consequently considerable."
Exact(5)
The risks of malaria in pregnancy are therefore substantial both to the mother and foetus.
The total years of life lost due to this illness are therefore substantial.
In addition to a decline in well-being and health, the indirect and direct costs and societal burden of insomnia are, therefore, substantial [ 24- 27].
These are therefore substantial and valuable studies that are analysed but also provide data to the community for further mechanistic studies.
The prevalence and incidence of cardiovascular disease increases exponentially with age. 1 2 3 The absolute numbers of cardiovascular events and deaths that could theoretically be prevented in older people are therefore substantial, although reductions in relative risk might be small (the geriatric paradox).
Similar(55)
There is therefore substantial concern about abnormalities in cloned humans.
The impact that phase approaches could have on the most diverse fields of application of X-ray imaging (medicine, biology, non-destructive testing, etc. ) is therefore substantial.
The potential influence of the school is therefore substantial, presumably especially so for those students who lack a certain threshold of capabilities when starting in higher education.
"The possible prize is therefore substantial, but this asset is still very much in its infancy and we will need to perform a considerable amount of work before drilling may occur".
The number of transcripts whose decay rate is slowed by IL-3 is therefore substantial, supporting the relevance of this posttranscriptional pathway to IL-3-supported survival, growth and differentiation blockade of 32Dcl3 myeloblasts.
There is therefore substantial scope for improving professional practice.
More suggestions(17)
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are therefore central
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are therefore significant
are therefore considerable
are therefore important
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are therefore fundamental
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are therefore paramount
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com