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These factors undermine the researcher's ability to make generalizations from the sample to the population and are therefore limitations.
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The unstandardised method of administration of the GPAQ survey and lack of data about response rates are, therefore, significant limitations of this study, as it is possible that non-respondents would show different patterns of response.
These are, therefore, subject to limitations that may result from how the data are mapped.
The absence of continuous light and noise measurements and lack of quantification of patient disturbances by staff are therefore further potential limitations.
These are therefore measures of activity (limitations).
First, these data are based on self-report and are therefore subject to the limitations of self-report bias.
These two aspects, reflecting social limitations, are therefore integrated in the modified PRAFAB-score (min-max = 6 20; range = 15).
Interventions to assist with aspects of cognitive functioning, such as memory problems, and associated functional limitations are therefore important in the milder stages of dementia as they may allow the person greater independence and can potentially minimize the risk of 'excess disability'.
We hypothesize that these alternative enzymes could require a metal other than Zn (or no metal) and are therefore expressed during Zn-limitation to replace or compensate for the decreased activity of their Zn-dependent counterparts.
New methods for introducing transgenes at specific positions are therefore needed to overcome the limitations of transposon-based strategies.
More studies are therefore necessary to overcome these limitations and provide further validity evidence to the scale.
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