Previously, high dose interleukin-2 (HD IL-2) was essentially the only efficacious treatment of metastatic RCC (mRCC).
In their Cochrane Review, Wilson and colleagues [ 12] concluded that CBT was the only definitely efficacious therapy for late-life depression.
In addition, when the herniated lesion is migrated upward or downward behind the vertebral body, both approaches, and even anterior cervical discectomy and fusion, are impractical, and corpectomy is commonly considered as the only efficacious treatment.
This is the essential, and after all the only efficacious security for the rights and privileges of the people which is attainable in civil society.
The only efficacious prevention is an anti-tobacco campaign aimed at the general population, patients exposed to carcinogens, and patients treated for a previous lung or head and neck cancer (recommendation, expert agreement).
This is the only way to develop efficacious prevention and treatment for these diseases.
With two recent systematic reviews and meta-analyses on the efficacy of lithium compared to placebo and other treatment options, it can now be concluded that lithium is the only drug that has been shown efficacious in the prevention of any mood episodes, manic episodes and depressive episodes in randomised trials not enriched for prior response to and tolerance of lithium.
If we assume that the cost to treat a patient in (where the treatment is not efficacious) is equal to the gain to treat a patient in S (where the treatment is efficacious), the utility assigned to the event that is rejected when the treatment is only efficacious in S, is given by.
Earlier research has shown that interventions targeting cognitive factors derived from Ehlers and Clark's theoretical model are not only efficacious for the treatment of chronic PTSD [ 54], but are also highly effective as an early intervention following trauma [ 55].
39 This suggests that service providers need to consider alternate approaches to ensure that the coping interventions for couples are not only efficacious and cost-effective but also accessible and sustainable.
