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The phrase "are the first indication" is correct and usable in written English.
It can be used when discussing evidence or signs that suggest something is happening or will happen.
Example: "The changes in temperature are the first indication of climate change affecting the region."
Alternatives: "serve as the initial sign" or "represent the primary evidence".
Exact(26)
Endothelial dysfunctions are the first indication for allogeneic corneal transplantation.
The piles of books and folders that overwhelm most surfaces are the first indication that Mrs Johnson might not be as self-possessed as she seems.
But the figures are the first indication that the continuing debate over racial profiling and police conduct could be having a serious impact on police procedures.
But the new disclosures are the first indication that Mr. Sullivan tried to impede and delay the audit that eventually proved his undoing.
They are the first indication from any Whitehall department of the impact of the 25% and 40% indicative cuts in budgets.
The suspensions, which originated from the S.E.C.'s New York office, are the first indication that some of the companies named in stock spam may be complicit in the scheme.
Similar(34)
These are the first indications of miR-31 potentially being involved in alcohol or anxiety related traits.
That was the first indication.
This was the first indication that she was someone special.
"This could be the first indication of a bomb.
It was the first indication that Moore was now a Person With Aids.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com