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Notably, the same residues or same regions are targeted by different E3 ligases or different signaling.
One example is the soybean lectin gene (Le1 ), where distinct regions are targeted by different soybean-specific methods.
While the integrase and reverse transcriptase proteins are targeted by different classes of antiretroviral drugs, the coding regions of these proteins can also be targeted by RNAi.
Very interesting phenomenon is that both transcripts NM_001030055 and NM_001173 of gene ARHGAP5 are the most sensitive off-target transcripts in both libraries, Ambion and Dharmacon, but are targeted by different siRNAs.
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These powerful genomic approaches are recommended by opinion leaders to identify specific pathways that could be targeted by different drugs depending on patients' subset [3].
Moreover, whether there are hot-spots on PD-1 or PD-L1 to be targeted by different therapeutic antibodies requires further investigation.
Such mouse models are available for most organs that may be targeted by different gene therapy methods.
We also observed that the CCAAT binding transcription factor At1g54160 is targeted by different mature miRNAs (1, 4, and 5).
Thus, in different datasets, the same pathway may be targeted by different molecules.
Different individual features of a tumour may be targeted by different drugs.
Proteins may contain multiple phosphorylation sites, which may be targeted by different kinases/phosphatases [ 2].
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