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Sex hormones are suggested to trigger these sex specific differences [ 2].
Strong TCR-MHC/peptide interactions are known to activate MAPKs, which are suggested to trigger BIM- and NUR77-mediated death effector pathways.
In response to strong TCR signals, MAPKs are suggested to trigger death pathways mediated by the BCL-2 family member BIM and the orphan nuclear receptor NUR77, respectively.
IH and sleep fragmentation are suggested to trigger an array of downstream effects (i.e., sympathetic activation, neurohumeral changes, inflammation, and oxidative stress), which are pathophysiological cascades that are common to the pathogenesis of cardiometabolic diseases [ 16].
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Recently, formic acid has also been suggested to trigger the acid crash of butanol production by C. acetobutylicum (Wang et al. 2011).
However, rAAV-based vaccines have been suggested to trigger functionally impaired long-term memory CD8+ T cell responses, in part due to poor dendritic cell (DC) transduction.
The adaptive training phase in our study consisted of 4 weeks, and has been suggested to trigger increases in fitness and health in Wistar rats [22], and may be an important factor in the protection of the knee joint.
Genetically-based loss of tolerance toward the gut flora was suggested to trigger the formation of anti-microbial antibodies in Crohn's disease [45].
Interestingly, mitochondrial ROS and the ROS-modified mitochondrial outer membrane may play a critical role in targeting damaged mitochondria in yeast cells [26], whereas the depolarization of mitochondria was suggested to trigger mitophagy in mammalian cells [5].
In intraspecific hybrids of Arabidopsis, an NB-LRR-type R gene homolog from one parent interacts with an allele at a single locus from a second strain, and the epistatic interaction between these genes is suggested to trigger an autoimmune-like response [3].
Multiple intrinsic mechanisms have been suggested to trigger cell death and progression to NASH.
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