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With the aforementioned results, the ESP part and bag filter part are suggested to function cooperatively in the hybrid ESP/BAG.
Although a small subpopulation of clonogenic CD138 negative B cells are suggested to function as cancer stem cells in MM [49], they are unlikely to have an impact on the underexpressed gene profile, when analyzing the tumor bulk.
Caspase-8 and -9 are suggested to function as upstream enzymes to cleave and activate caspase-3 and -7 in apoptotic cells [1] [3], and it is reasonable to ask whether the caspase activation machinery in apoptosis is also involved in the progression of cell cycle.
In plants, P4Hs are suggested to function as oxygen sensors under hypoxia stress [ 67, 68].
Similar to RA, many endogenous molecules are present in the OA joint where they are suggested to function as DAMPs that can activate PRRs.
Clathrin and the retromer complex are suggested to function in consecutive retrograde sorting steps on early endosomes (Popoff et al. 2007).
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A strictly conserved glutamate residue is suggested to function catalytically in thioester proteins.
AQP1 has been suggested to function as an ion channel upon cGMP activation, although this idea has been controversial.
Chromatoid bodies (CBs) are characteristic spermatid organelles, which were suggested to function in RNA storage and small RNA processing but whose functions remain largely unknown.
For example, cell cycle, DNA methylation, and tumor progresses have been suggested to function together under certain circumstances (Robertson et al., 2000; Wu et al., 1993).
Consequently, a number of nucleases have been suggested to function in ICL repair, including MUS81-EME1, XPF-ERCC1 and SLX4-SLX1 (Douwet et al., 2014).
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