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Finally, it is possible that a threshold effect might operate whereby lower levels of ERK1/2 activation are sufficient to activate RSK2, but an increased level of activity is required for RSK1.
6 Data derived from in vitro and in vivo studies have determined that tissue DHT levels of 0.5 1.0 ng/g (the range observed in prostatic tissue of castrated patients) are sufficient to activate the AR, stimulate expression of AR-regulated genes, and promote androgen-mediated tumor growth.
Notably, low loadings of biocompatible CuBr2 electron transfer mediator and topaquinone-like organocatalyst are sufficient to activate, under ambient air, the α-C H bond of non-activated primary amines that are known to be challenging substrates for non-enzymatic catalytic aerobic systems.
Merkel cells sense mechanical stimuli (through Piezo2), fire action potentials, and are sufficient to activate downstream sensory neurons.
Schwarz, H., Schmittner, M., Duschl, A. & Horejs-Hoeck, J. Residual endotoxin contaminations in recombinant proteins are sufficient to activate human CD1c+ dendritic cells.
This study suggests that the levels of crustal stress in the Northeastern U.S. are sufficient to activate fractures associated with the Ramapo Fault System.
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These data demonstrate that PAK1 inhibition itself is sufficient to activate PPARγ transcriptional activity.
Thus the endogenous potential of procoagulant activators was sufficient to activate fibrinogen and to terminate bleeding.
While both stimulatory and secondary structures in CpG DNAs were required for pDC activation, CpG motifs were sufficient to activate B cells.
NAIP5 also is required for NLRC4 activation by the minimal C-terminal flagellin peptide, which is sufficient to activate NLRC4.
Thus, depleting p62 is sufficient to activate impaired autophagy in lkb1 mutants and extend survival.
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CEO of Professional Science Editing for Scientists @ prosciediting.com