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The phrase "are substantially more" is correct and usable in written English.
It can be used when comparing quantities, qualities, or characteristics to indicate a significant difference.
Example: "The new model's features are substantially more advanced than those of the previous version."
Alternatives: "are significantly greater" or "are considerably more".
Exact(60)
Moreover, high-tech establishments have a substantial fraction of scientists, and are substantially more likely to invest in R&D.
And they are substantially more expensive.
Other possibilities are substantially more bellicose.
These results are substantially more precise than previous measurements.
Both of GM's programs are substantially more expensive.
The Democrats are substantially more pro-Palestinian than the Republicans.
Ferenstein also found that tech founders are substantially more liberal on immigration policy than Democrats generally.
The structures of trimer-NH2, tetramer-NH2 and pentamer-NH2 are substantially more complex.
It is demonstrated that maximin optimal designs are substantially more efficient than uniform designs.
"Clients are substantially more interested in consigning to a themed auction," Mr. Lowry said.
Studies show that the uninsured are substantially more likely to require hospitalization for festering medical problems like diabetes.
More suggestions(15)
are somewhat more
are appreciably more
are vastly more
are considerably more
are dramatically more
are greatly more
are almost more
are drastically more
are noticeably more
are markedly more
address substantially more
involve substantially more
explain substantially more
contribute substantially more
expect substantially more
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com