Sentence examples for are substantially less active from inspiring English sources
The novel proteins are substantially less active, and may function by different mechanisms than the natural proteins they replace.
Docetaxel metabolites are substantially less active than the parent drug; hence, CYP3A-mediated metabolism is the major route of inactivation.
When fit to a line, the slope was 0.26 zmol μM 1 s–1, an order of magnitude less than that seen for the tissue-cultured cells in this work and in prior work using other tissue-cultured cells, suggesting that the peptidases responsible for degradation of peptide VI-B are substantially less active in the PDX tumor cells compared to that in tissue-cultured cells.
Of note, the Vpu of the T cell line-adapted NL4-3 clone, which has been utilized in most previous studies, was substantially less active in reducing IKKβ-induced NF-κB activation (62.0% ± 9.5%) than the Vpu proteins of 28 other HIV-1 M strains analyzed (5.3% ± 1.3%; p < 0.0001).
Although all 17 isolates possessing tccC were found to produce bipyramidal crystals and had previously been found toxic to lepidopteran larvae, sporulated cultures of selected tc-positive isolates were found to be substantially less active against gypsy moth larvae than was IBL 455, which was isolated from a 1980 preparation of Dipel® (Abbot Laboratories, Chicago, IL, USA).
In contrast, both compounds were substantially less active against HDMX with IC50 values of 1300 ± 100 nM and 2000 ± 300 nM.
It is a potent inhibitor of EGFR with an IC50 of 39 nM in an autophosphorylation assay, where it was substantially less active toward HER2 with an IC50 of 1,255 nM [ 77].
Adults with intellectual disability (ID) are substantially less physically active than the general community [ 1– 3] which may contribute to preventable physical and mental health problems [ 4, 5].
