The phrase "are substantially elevated" is correct and usable in written English.
It can be used to describe a significant increase or rise in a particular context, such as prices, levels, or conditions.
Example: "The costs of living in urban areas are substantially elevated compared to rural regions."
Alternatives: "are significantly raised" or "are greatly increased."
Using the method of quantitative (fluorescence) reverse transcriptase polymerase chain reaction, we demonstrated previously that FMR1 mRNA levels are substantially elevated in premutation (55 200), FMR1 mRNA levels remain significantly elevated (mean 3.5-fold elevation; P = 6.7 x 10 -3)) relative to normal controls, even for alleles exceeding 300 repeats.
Conversely, asymmetric dimethylarginine concentrations are substantially elevated by native or oxidized LDL cholesterol [36].
The pro- and active-forms of plasma MMP-9 are substantially elevated in FXS individuals compared to typically developing age-matched controls although a significant overall correlation between reduced MMP-9 activity and observed improvement in the Clinical Global Impression-Improvement (CGI-I) was not observed [18].
eIF4E protein levels are substantially elevated in many cancers including colon, breast, bladder, lung, prostate, gastrointestinal tract and head and neck cancers; Hodgkin's lymphomas and neuroblastomas [4], [9], [19].
Pneumococcal disease rates are substantially elevated in certain minority populations, including African-Americans, Alaska natives, and Native Americans.
Since vitamin E is a fat-soluble substance and it may take months before tissue levels are substantially elevated (30, 31), short trials may be uninformative.
Such leukocytosis is reflected in the white blood cell count, which may be substantially elevated above the normal upper value of 10,000 cells per cubic millimetre of blood.
Among the altered proteins that could potentially mediate this increased host cell interaction is the BON-protein (BCAM0280), which was substantially elevated with time of colonization in both individuals' isolates.
Additionally, circulating levels of BUN and creatinine were substantially elevated in acute IR animals and were reduced by lower dosage of sitagliptin treatment and more further reduced by higher dosage of sitagliptin treatment.
To further assess the ototoxicity of the HA perfusion, we measured compound action potential (CAP) thresholds following the perfusion of HA, and found that the CAP thresholds were substantially elevated.
High resolution mass spectrometry (HRMS) analysis indicated that fipronil and its known derivatives were routinely present in all samples, but concentrations were substantially elevated near wastewater treatment plant outfalls (range 10 500 ng/L combined), suggesting that they predominate as environmental sources.
