'are substantially changed' is a correct phrase in written English.
You could use it to describe something that has undergone a significant transformation, like in the sentence, "The plans for the project have been substantially changed since last month."
When not praising NBC's upscale neighborhood, he was citing the stability of its residents -- only Tuesday and Friday nights are substantially changed.
The BMA is correct that the current proposals are inadequate as a basis for renegotiation, and until they are substantially changed then there is nothing to discuss.
Nick Clegg has warned David Cameron he will not ask Liberal Democrat MPs and peers to support the Government's health reforms unless they are "substantially changed".
Gene expression profiles in Polycomb-deficient ES cells are substantially changed but do not abrogate self-renewal [ 69].
In summary we conclude that the pharmacokinetics of camptothecin are substantially changed by binding it to a polymeric backbone, showing controlled prolonged exposure of camptothecin.
That may be true, Democrats and some Republicans say, if the tax package is substantially changed.
The properties of metals can be substantially changed by various heat-treatment processes.
The paper that appears next Sunday will be substantially changed from the first edition of the Observer on 4 December 1791.
But it seems unlikely that bird flu surveillance and control programs will be substantially changed based on this research.
On Sunday that balance was substantially changed: this time Middle Eastern and North African influences were heard in the modal vocal lines and instrumental solos.
Senate officials say there are probably 8to1010 other Democratic senators who feel as Mr. Levin and Mr. Kennedy do, and who would probably vote against a resolution unless it is substantially changed.
