The phrase "are substantial through" is not correct and does not convey a clear meaning in written English.
It may be intended to express that something is significant or considerable in a certain context, but the phrasing is awkward and unclear.
Example: "The findings of the study are substantial through various methodologies, indicating a strong correlation."
Alternatives: "are significant in" or "are considerable across".
Despite differences between basic chromosome numbers and genome size between coffee and grapevine (respectively ~704 Mbp for 11 chromosomes [ 3] and ~475 Mbp for 19 chromosomes [ 16]), the analyses of the 282 single-locus COSII loci revealed that the synteny relationships are substantial but fractionated, through the conservation of numerous blocks.
The economic consequences through productivity losses are substantial [6].
The university's presence in a smallish city (which has a population of approximately 330,000) is substantial, and through a close relationship with the city council it has expanded into the city.
How much the political turmoil of these years affected Newton and his family is unclear, but the effect on Cambridge and other universities was substantial, if only through unshackling them for a period from the control of the Anglican Catholic Church.
During 2011, there was substantial, growing momentum through GAVI for use of rotavirus and pneumococcal conjugate vaccines [ 79].
The gross international differences between HPV subtypes (Yamada et al, 1997) indicate that infections often involve viruses that have evolved in the region over many centuries, but now there is substantial intercontinental mixing through increased migration.
The poorly understood chemistry of electrode-electrolyte interfaces implies that there is substantial room for improvement through a careful design of the materials involved.
Although one cannot be sure what will occur at yet longer follow-up periods, judging from other radiation exposed groups it would be expected that there would be substantial raised risks persisting through 40 or more years of follow-up (Committee on the Biological Effects of Ionizing Radiation (BEIR), 1990).
Therefore, while the costs of conservation through ELS may be substantial, the economic value of ecosystem service benefits provided are likely to be substantially greater.
"This is probably a throwback to a time when man's availability of nutrition was limited and the extra requirement of calories to get through puberty was substantial," said Wilkin.
