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The phrase "are substantial differences in" is correct and usable in written English.
It can be used when discussing variations or distinctions between two or more subjects or items.
Example: "In the study, it was found that there are substantial differences in the effectiveness of the two treatments."
Alternatives: "there are significant differences in" or "there are considerable differences in".
Exact(60)
There are substantial differences in cost between different mask/respirator options.
However, there is evidence indicates that there are substantial differences in the neurobiological mechanisms of different drug addiction [ 83].
However, there are substantial differences in child physiology and behavior at different ages that can have a substantial impact on exposure to pesticides.
There are substantial differences in the amount of research concerned with different disorders.
There are substantial differences in vaccination coverage and timely vaccination between different geographical areas in South Africa.
The estates of decedents are administered quite differently in the two systems, and there are substantial differences in the amount of freedom of disposition that each system gives the deceased.
Apart from obvious dissimilarities in input values and assumptions – reflecting the different populations and health-care systems simulated – there are substantial differences in the structures of the models.
For example, there are substantial differences in Hempstead and Great Neck.
But everything we know suggests that there are substantial differences in company quality within industries, as well as across industries.
There are substantial differences in reservoir performance characteristics between conventional and ultra-low permeability reservoirs.
There are substantial differences in system design and performances between GCI and PET.
More suggestions(18)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com