The phrase "are substantial differences between" is correct and usable in written English.
You can use it when discussing or comparing two or more items, concepts, or situations to highlight the notable distinctions among them.
Example: "In the study, it was found that there are substantial differences between the two methods of data collection."
Alternatives: "there are significant differences between" or "there are considerable differences between".
Both studies contain sufficient numbers of HCV seropositive and seronegative subjects to permit analysis of risk factors, but there are substantial differences between the studies due to different target populations and inclusion criteria.
A significant issue related to the bonding of dissimilar materials is, nevertheless, that there are substantial differences between adherend material properties, which often lead to different structural and fracture responses.
For example, ED scores in primates under the biological species concept [35] are tightly correlated with ED scores under the phylogenetic species concept [36] (r2 = 0.65 on a log-log scale), in spite of the fact that there are substantial differences between the two: the number of primate species differs by 50%.
The models have all problems of reproducing the magnetization current details and there are substantial differences between the models in residual flux estimation resulting in quite different inrush patterns.
8 Life expectancy in the general population varies by age, sex, and race, 9 and there are substantial differences between low and high income countries, which are reflected in different mortality rates in people with HIV. 10 Furthermore, the pattern of the HIV epidemic varies by country.
There are substantial differences between the two cases.
The Senate bill, once completed, must be reconciled with the bill adopted by the House last month, and there are substantial differences between the two.
Yet, there are substantial differences between the static and the dynamic model.
There are substantial differences between this context and the biobanking context.
Note that there are substantial differences between the questions that have been used in the VM and the NTU.
(I, 3. 4. p. 68) There are substantial differences between people over the content of practical principles.
