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The phrase "are substantial changes in" is correct and usable in written English.
It can be used when discussing significant modifications or alterations in a particular context, such as policies, plans, or conditions.
Example: "The report indicates that there are substantial changes in the company's operational procedures that need to be addressed."
Alternatives: "are significant alterations in" or "are major modifications in".
Exact(9)
A major concern is that the supply of electricity might exceed demand for about 1,000 hours each year by 2020 unless there are substantial changes in the way electricity is managed in Denmark, Mr. Birkebaek said.
Mr. Altmire, who did not attend the session but planned to watch it later on video, said, "I don't see very many at all who voted no who are going to switch their votes unless there are substantial changes in the bill".
Along with the climatic shifts documented by the paleosols there also are substantial changes in alluvial architecture and paleotopography.
The question arises if the experiments obtained with these columns are scalable, because there are substantial changes in extra column volume when going from a very small scale to a benchtop column.
Other neurobiological explanations for emotion dysregulation during adolescence are substantial changes in the neurotransmission of dopamine (e.g., [ 59]) and changes in endocrinology and hormonal status (e.g., [ 60]).
If the gene expression patterns are predictive of hormone levels, then the data indicate that there are substantial changes in hormone biology.
Similar(50)
In recent decades, there have been substantial changes in mortality from urologic cancers in Europe.
Since the 1990s, there have been substantial changes in the composition of immigrant groups to arrive in Spain.
Although there were substantial changes in society and political structures, the break with Antiquity was not complete.
Nevertheless, there were substantial changes in the self-selected postures during interactions with each of the haptic environments.
There have been substantial changes in the treatment of DLBCL in the past two decades.
More suggestions(17)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com