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Cellular acetylation levels are stringently controlled by two enzyme families: the histone acetyltransferases (HATs) and histone deacetylases (HDACs) (Shahbazian and Grunstein, 2007).
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Cellular proliferation is an energy consuming activity that is stringently controlled by checkpoints of the cell cycle [1].
Through static experiments, the concept was developed that the amount and pattern of thrombin generation and, hence, of fibrin clot formation, is stringently controlled by platelets [12], [13].
However, progression through the cell cycle is stringently controlled by the regulation of the metabolic pathways involved in energy generation [10], [11], [71].
This coordination is stringently controlled by gene networks that contain both positive and negative components.
Cytokine responses have to be stringently controlled by a number of key regulatory proteins, such as the suppressors of cytokine signalling (SOCSs) family members.
Owing to its cytotoxicity, bacterial intracellular levels of cysteine are stringently controlled via several modes of regulation, including cysteine degradation by cysteine desulfhydrases and cysteine desulfidases.
Secondly, the system can be stringently controlled and finely tuned by adding additional drug-responsive ribozyme switches (up to four), therefore achieving lower basal gene expression levels.
Such interactions must be stringently controlled for cell-based tissue engineering and regenerative medicine therapies, and methods for studying and controlling cell cell interactions are being developed using both biomedical and engineering approaches.
Cryptic plasmids by definition have no detectable effects on their hosts, so the copy number of pWV01 in its native host must be stringently controlled.
Development and homeostasis in the retina must be stringently controlled for normal vision [ 6].
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