Sentence examples for are specifically mediated from inspiring English sources

These signals are specifically mediated by the delta isoform (PI3K δ) of PI3K that is mainly expressed on B cells.

Thus we presume that the observed phenotypes in rotenone-treated ARPE-19 cells are specifically mediated by mitochondrial respiration complex I inhibition.

These data suggest that the interactions between the RRM and GR domains of HvGR-RBP1 either require the complete HvGR sequence, or that these interdomain interactions are specifically mediated by the 25 most C-terminal residues of HvGR.

In all of the above experiments, only negligible currents were elicited in cells transfected with empty vector (pcDNA), showing that the currents induced by membrane curvature are specifically mediated by Piezo1.

The effects of the A1AR and A2BAR agonists appeared to be completely counteracted by the selective AR antagonists, DPCPX and MRS1754, indicating that the anti-proliferative effects of CHA and BAY606583 on CSCs are specifically mediated by the activation of A1AR and A2BAR, respectively.

To address whether the effects of Torin1 are specifically mediated by mTORC1 inhibition, we also treated apc mcr/mcr zebrafish with rapamycin, an allosteric inhibitor of mTORC1 that acts through a distinct mechanism and through a separate binding site in the mTORC1 complex (Sarbassov et al., 2006).

It is also clear that RBC necroptosis induced by hCD59-specific PFTs is specifically mediated by endogenous FasL and not TNF- α or TRAIL.

Collectively, our data suggest that the deubiquitination of ANXA1 is specifically mediated by HAUSP, and HAUSP-mediated deubiquitination of ANXA1 may be important for ANXA1's damage response function in the nucleus upon UV.

Additionally, the outcome of a directed yeast two-hybrid assay identify importin α6 as a specific partner of BRMS1 thus speculating that BRMS1 nuclear import could be specifically mediated by the reported nuclear transporter.

Moreover, the E2 effect in these cells was specifically mediated by ER α as deduced by the effect of the specific ER α agonist 4,4′,4′′- 4-propyl- 1H -pyrazole-1,3,5-triyl) trisphenol (PPT) or the specific ER β agonist 2,3-bis(4,4′,4′′- 4-propyl- 1H -pyrazole-1,3,5-triyl

These data demonstrate that the ubiquitination of p62 is specifically mediated by parkin, while the disease causing mutants that have impaired E3 ligase activity fail to ubiquiniate p62 for its subsequent degradation (Fig. 5F).