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Studies have shown that monocyte activation and infiltration are specifically implicated in the initiation of chronic inflammation and atherosclerosis (12).
Among these, Sox5, Sox6 and Sox9 are specifically implicated in chondrogenesis (Schepers et al., 2002), and all three seem to be important for disc development.
Fisher et al. (66) used multimodal imaging to show that 5-HT receptors are specifically implicated in emotion-modulated coupling of amygdala and OFC.
As shown in Table 1, nine of the 99 target genes differentially expressed in SNAI1-DN clone are specifically implicated in EMT and in matrix remodelling, these include several members of the PA system.
Because many of these genes are specifically implicated in the response to ionising radiation, women who carry pathogenic alleles in these genes might be more sensitive to radiation-induced BC than non-carriers, as suggested by recent studies [ 5, 6].
Genetic polymorphisms in the CYP gene family are associated with poor or intermediate metabolism of many drugs used to treat tropical infections (10 ) and several of these enzymes are specifically implicated in the metabolism of PQ (11 ) and other antimalarial drugs (12 ).
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Some of these mutants are probably involved in auxin-related processes, and a very few, including rh2, Lrt1, and ral1, seems to be specifically implicated in root-specific mechanisms.
In addition, the chemokine receptor CCR4 (specific for CCL17 and CCL22) has been specifically implicated in Treg migration into tumors [36], [37], and we are currently examining alterations in the levels of this and other chemokine receptors on Tregs following GITR ligation in vitro and in vivo.
Sec14l3 has been specifically implicated in the intracellular transport of α-tocopherol53 and has been proposed as sensor of liposomal lipid-packing defects in the lung51.
These data demonstrate that the hippocampal CA3-region is specifically implicated in spatial information processing and seems to be involved not only in acquisition but also in consolidation of spatial information.
The STS has also been specifically implicated in processing various forms of anger [29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com