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Projection neurons of mammalian olfactory bulb (OB), mitral and tufted cells, have dendrites whose morphologies are specifically differentiated for efficient odor information processing.
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Finally, the phasiPH12-1 phareRNAspecificallyicalocatedated in pollen sac of differentiated stamens subsequent to miR2118 detection (Fig. 4).
After a cell is fully differentiated, many genes are specifically silenced by polycomb proteins and lncRNA-mediated histone methylation rather than by a large army of negative transcriptional factors [ 7].
The sensory epithelia of the inner ear are very specifically differentiated, enabling the olm to receive sound waves in the water, as well as vibrations from the ground.
OsIAA11 belongs to the same expression cluster than OsIAA31 and is specifically expressed in differentiated roots and stems [ 20].
The mbp gene is specifically expressed in differentiated oligodendrocyte lineage cells, including oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.
As shown in Figure 4, 11 genes characterized committed luminal cells (middle panel); an additional 7 genes were specifically associated with differentiated luminal cells (lower panel).
Two miRNAs, miR-135a and miR-367, were strongly up-regulated in differentiated myotubes to an extent comparable to that measured for miR-1 and miR-133a, previously shown to be specifically up-regulated in differentiated murine muscle cells [12].
Immunoblotting revealed that the expression of the extended- and truncated-C/EBPα isoforms were specifically downregulated in the differentiated HL-60 cells.
It is noteworthy that Ccnd2 expression may be specifically elevated in poorly differentiated breast cancer cells that exhibit features of epithelial-mesenchymal transition and a higher potential for metastasis [ 32].
The loss of differentiated cardiomyocytes was specifically due to loss of Xic1, as this phenotype could be rescued to a large extent by co-injection of Xic1 mRNA.
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