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This work, termed DYHM for "Dynamic Hierarchical Model", builds on previous studies that used mRNA abundance as a proxy for protein abundance, and when applied to yeast cell cycle data [4] showed the existence of protein complexes that are specific to cell cycle phases [5], [6].
These results suggest that the responses to SFN treatment are specific to cell types.
Regulators of necroptosis are specific to cell types being different for the apoptosis-competent and the apoptosis-incompetent cells.
It appears that the effects of HDI such as TSA and SB on MMP (matrix metalloproteinase) expression are specific to cell types.
Targeted agents that are specific to cell surface markers overexpressed in tumor cells would avoid potential side effects on normal tissue.
In contrast, binding sites identified in for example ChIP-sequencing experiments, such as generated by the ENCODE consortium [ 34], are specific to cell type and experimental conditions.
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In addition to this, further it was proposed that the inflection of surface charge on mesoporous silica nanoparticles uptake is specific to cell type [106].
This disparity did not lead to differences in cell death, indicating that jnk2 expression does not mediate cellular response to DSBs but rather is specific to cell death in response to cell cycle initiation.
Indeed, it has been reported that their activation can be specific to cell lineage as well.
It has been shown that radiation response is specific to cell types from different tissue origins.
This, however, is specific to cell type and to the stimulus and is dependent on endogenous PDE activity.
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