The phrase "are some substantial differences" is correct and usable in written English.
You can use it when discussing or comparing two or more items, highlighting that there are notable distinctions between them.
Example: "When examining the two proposals, it is clear that there are some substantial differences in their approaches to sustainability."
Alternatives: "exist significant differences" or "are considerable differences."
Still, there are some substantial differences between now and 1993 that have led many politicians to argue that Mr. Bloomberg would be making a mistake if he tried to win simply by repeating Mr. Giuliani's campaign of that year.
In general we pattern our exclusion rules after Smith and Welch (1989), although there are some substantial differences.
Although obvious similarities between diatoms and chlorophytes exist, there are some substantial differences in their lipid metabolism.
On the savings side of the equation, we can see that there are some substantial differences between the ways that banks in some states reward their customers and clients relative to other states.
There are some substantial differences between the PANA approach and most functional Enrichment Analysis methods.
Using the same model structure there are some substantial differences, and a good deal of instability when estimating the interaction terms, as compared to those derived for GAIL.
Although there were some substantial differences in these parameters between cohorts, which may affect interpretation of the dosing results, examination of the mean values for TSAT and Hb levels across cohorts suggest that adequate iron delivery to the erythron was likely during the study.
There are some substantial unexplained differences in parameters between classes, but the time and magnitude distributions of the individual earthquake contributions are such that the model is suitable for three-month testing at M ≥ 4 and for one-year testing at M ≥ 5.
But given the zoological, behavioral and ecological characteristics of wildlife populations, there are also some substantial differences that need to be taken into account when planning for, implementing and interpreting data from investigations into wildlife health.
There are also some substantial differences in the EST distribution within the 'carotenogenesis-rich' libraries.
Critics of Peter Kareiva, the lead scientist for the Nature Conservancy, had the floor in the last post and now Kareiva reacts: The vigor of the responses and debate surrounding "Conservation in the anthropocene" and the published discussion of the original article reveals that there are some substantial issues and differences in the conservation community worth working our way through.
