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The phrase "are some significant differences" is correct and usable in written English.
It can be used when discussing or comparing two or more subjects to highlight the distinctions between them.
Example: "When examining the two theories, it becomes clear that there are some significant differences in their underlying principles."
Alternatives: "exist notable differences" or "are considerable distinctions".
Exact(47)
Although there are some significant differences in the way a wound heals in various organisms, and at different developmental stages, tissue repair generally takes place following a well-described series of overlapping steps (Martin, 1997; Gurtner et al., 2008).
There are some significant differences, of course.
Although Obama tried to blur most distinctions between himself and Romney, there are some significant differences.
But there are some significant differences, and not only behind the bench.
There are some significant differences between the iHome and Sonos products.
As insurers work to determine the form these policies will take, there are some significant differences among the few companies offering them.
Similar(12)
A MANOVA indicated that there were some significant differences in how the different nationalities ranked the four types of responsibility F (12, 1176) = 4.02, p < .001 (Table 5).
A MANOVA indicated that there were some significant differences in how the different nationalities rated the importance of the four types of responsibility F (12, 1173) = 7.12, p < .001 (Table 5).
Among the different tissues, there seem to be some significant differences with regard to the ratio of DMRs subjected to methylation and demethylation.
With more established designers, there would probably be some significant differences from the Proenza Schouler auction, Ms. White said.
"I think there's some significant differences between me and the current occupant of the White House," Rubio said, before laying out those differences.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com