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The phrase "are so substantial the" is not correct in written English as it is incomplete and lacks clarity.
It could be used in a context where you are trying to emphasize the significance of something, but it needs to be part of a complete sentence.
Example: "The changes in policy are so substantial that they will affect the entire organization."
Alternatives: "are so significant that" or "are so important that".
Exact(1)
Indeed the economic benefits of height are so substantial, the economists say, that many boys who are short might benefit from human growth hormone replacement therapy, such as Humatrope from Eli Lilly.
Similar(59)
The label and back story are so substantial that the piece starts to resemble a large, labor-intensive illustration of a text; it doesn't generate enough meaning on its own.
The challenges facing the country today are so substantial that further delay imperils the Republic and warrants another reduction in the supermajority requirement.
But, said Mark V. Pauly, a panel member and professor at the University of Pennsylvania, "the benefits of these vaccines are so substantial that worrying about the last penny of spending seems to be a foolish economy".
Fitch Ratings said Wednesday it cut Toyota Motor to AA rating, from AAA. "In Fitch's view, the negative developments in the industry are so substantial and fundamental that even the strongest player Toyota can no longer support a 'AAA' rating," according to Tatsuya Mizuno, director of Fitch Ratings, in the report.
The British are not convinced that markets will be soothed by a promise of slow, complicated treaty changes to toughen up the rules, that are so substantial that (I am told) the Irish government has warned Berlin that they would trigger the need for a referendum in Ireland.Two, Mr Cameron does not want a big treaty change right now.
It covers some of the scars, but not all of them because some are so substantial they would not take the ink.
Because the NGSS are so substantial, assessments are bound to be based on the performance expectations alone.
Indeed, the implied reductions in Social Security benefits for future retirees are so substantial, they raise questions about the viability of protecting benefits for current retirees, older workers, disabled workers, and survivors while diverting payroll taxes into individual accounts".
The savings are so substantial in part because their lower gross income cuts the taxable share of their Social Security from 85%to50%0%.
However those costs will not materially impact the economics of their business since the royalties are so substantial.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com