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The phrase "are so difficult to" is correct and usable in written English.
It can be used when describing something that presents a significant challenge or obstacle to accomplish.
Example: "These math problems are so difficult to solve that many students struggle with them."
Alternatives: "are extremely hard to" or "are quite challenging to".
Exact(60)
Three-toed sloths are so difficult to maintain in captivity that little is known about their breeding behaviour and other aspects of their life history.
Their experiences are so difficult to get at!
"That's why these diabetes findings are so difficult to interpret.
But they are so difficult to achieve that it is effectively a pay cut".
Not all of Pembrokeshire's hidden delights are so difficult to reach.
The "rending of confidence is one reason that recessions are so difficult to forecast," he said.
This is yet another reason the markets are so difficult to beat.
This unpredictable rending of confidence is one reason that recessions are so difficult to forecast.
This article and the comments below perfectly illustrate why Health budgets are so difficult to control.
I love the symphonies, but they are so difficult to get across.
But it also explains why they are so difficult to dispose of.
More suggestions(15)
are consequently difficult to
are however difficult to
are even difficult to
are accordingly difficult to
are very difficult to
are then difficult to
are so tough to
are so laborious to
are less difficult to
are so damaging to
are so sensitive to
are so annoying to
are so wonderful to
are so open to
are so glad to
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com