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The phrase "are significant changes in" is correct and usable in written English.
It can be used when discussing alterations or modifications in a particular context, such as research findings, trends, or policies.
Example: "In the latest report, there are significant changes in the company's financial strategy that could impact future growth."
Alternatives: "there are notable alterations in" or "there are important modifications in".
Exact(50)
There are significant changes in the city's northern suburbs.
"We're finding that there are significant changes in the central nervous system and spinal cord that cause pain to become amplified and persistent even after the injury has gone away".
The MPs warn that there is a "very real danger of unmanageable growth" in the prison population, which at more than 85,000 is already at record levels, unless there are significant changes in both the current "tough rhetoric" and policy on sentencing.
At Mach numbers in excess of the critical Mach number (that is, speeds at which the airflow exceeds the speed of sound at local points on the airframe), there are significant changes in forces, pressures, and moments acting on the wing and fuselage caused by the formation of shock waves.
There are significant changes in the magnitude of the stresses.
In cases where there are significant changes in format when an instrument is adapted from paper to electronic format, equivalence testing might be required [17, 18].
Similar(9)
There are going to be significant changes in religious communities.
"There's no question that there have been significant changes in the markets over the last few years," Mr. Ketchum said.
There were significant changes in terms of the impression organized labour made on politics.
Edwards put it more bluntly, stating what is obvious to the players: there will probably be significant changes in the off-season, win or lose.
Recently, there have been significant changes in engineering accreditation practices in Australia and North America.
More suggestions(20)
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are significant developments in
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are important changes in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com