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These results basically support the hypothesis that developmental and non-cell autonomous (glial) effects are shared in multiple neurodegenerative disorders.
Because evolutionarily conserved sites may be more functional than nonconserved sites [51], [52], this observation suggests that the tissue-specific binding sites are more likely to be functional than the binding sites that are shared in multiple tissues.
Because these mutant lines were produced by tissue culture and are derived from a relatively small number of induced calli, some of these mutations are shared in multiple independently regenerated plants [ 27].
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And then this information should be shared in multiple forums in easy to understand ways so prospective students can make the best possible decisions about college.
Our findings that most of the pSNMs that we identified were shared in multiple samples suggested the widespread nature of postzygotic mutations during embryogenesis and early development.
We observed that 25% of the variants on average (14% in Family I, 29% in Family II, 35% in Family III) were shared in multiple affected members in each family, whereas 75% on average (86% in Family I, 71% in Family II and 65% in Family III) were present only in single affected member in each family (Table 2).
Given the rapid turnover of TF binding within a mammalian lineage (Stefflova et al., 2013), requiring combinatorial binding to be shared in multiple mammals is a strict filter that provides evidence that these biochemical interactions are under selection, even if the percent identity in the sequence alignments themselves is not exceptional.
However, in a recent study of intratumor heterogeneity, PBRM1 point mutation was considered ubiquitous, while point mutation of both SETD2 and KDM5C was shared, in multiple biopsies from the primary RCC in individuals with metastatic RCC (KDM6A, BAP1 or ARID1A point mutation were not present in the 4 RCC in the study).
These transduplications are shared in some cases by multiple copies suggesting that they do not inactivate the transposition of PIF elements.
Through Building Mutual Trust and Rapport, roles are clarified and key players come together as bits of information are shared in manageable quantities with multiple contacts over time.
Time-sharing systems allowed a computer's resources to be shared in rapid succession with multiple users, cycling through the queue of users so quickly that the computer appeared dedicated to each user's tasks despite the existence of many others accessing the system "simultaneously".
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CEO of Professional Science Editing for Scientists @ prosciediting.com