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The phrase "are several major differences" is correct and usable in written English.
It can be used when discussing or comparing distinct characteristics or features between two or more subjects.
Example: "When examining the two theories, it becomes clear that there are several major differences in their approaches to problem-solving."
Alternatives: "exist several significant differences" or "present multiple key differences."
Exact(7)
While EDs in the Colombian capital city, Bogotá, resemble US urban EDs in some ways, there are several major differences that raise questions of existing overcrowding and what will happen with the anticipated increase in ED utilization and growing population.
There are several major differences between the two breeds, with the primary difference being the size.
There are several major differences between solitary and social insects with respect to the potential for transmission of parasites, primarily relating to the behavioural adaptations that may prevent parasite attacks and the lack of immune genes.
Naturally, there are several major differences between human disease and animal models.
However, there are several major differences between these two meta-analyses and our study.
There are several major differences between the designs of our studies, which likely account for the novel results that we are reporting with p21.
Similar(53)
There are several major hospitals.
There are several major data sets.
There are several major problems with this.
There were several major structural differences in the zone of the primary tissues between non-flooded roots and adventitious roots.
There were also several major differences in study populations across these trials, the major one being the inclusion in PRINCE and TNT, but not CAP, of individuals with documented CHD or CVD events.
More suggestions(2)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com