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The phrase "are several large differences" is correct and usable in written English.
It can be used when discussing or comparing multiple significant distinctions between two or more subjects.
Example: "When analyzing the two reports, it became clear that there are several large differences in their methodologies."
Alternatives: "there are numerous significant differences" or "there are many substantial differences."
Exact(1)
Although there are several large differences, all are largely similar in the sense that they all describe 4 stages (in order of increasing severity): 1) uncomplicated HFMD/herpangina, 2) with CNS involvement, 3) with autonomic dysregulation, and 4) with cardiopulmonary failure.
Similar(59)
But there are several big differences.
There are several large varieties of oboe.
Most impressive were several large whitefish.
Instead there were several large shipping containers.
Although the trend of flux ranges in ColiCore and ColiGS are also similar, several larger differences can be observed.
There are several crucial differences between the two bills.
But there are several significant differences between the cases.
There are several fundamental differences between planar and spherical triangles.
However, there are several distinctive differences.
There are several differences.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com