There are several different models.
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features.
AFPs have been grouped into several different subtypes based on structure, for example, type 1 AFPs consist of a long amphipathic α helix, whereas type 2 AFPs are cysteine-rich globular proteins containing several disulfide bonds.
In the rodent (prefrontal) cortex, interneurons have been categorized into several different subtypes based on their electrophysiological, morphological, and chemical properties (Kawaguchi and Kondo 2002; Beierlein et al. 2003; Couey et al. 2007; Ascoli et al. 2008; Fanselow et al. 2008; Van Aerde et al. 2009).
It is now clear that several different subtypes of CRC exist, defined by the acquisition of specific different genetic abnormalities that drive the cell transformation.
First, ALK is strongly expressed in several different subtypes of human breast cancers, in a pattern not consistent with normal tissue [ 84].
Influenza is caused by two strains, A and B, and several different subtypes that are designated by the two proteins that stud the viral surface, hemagglutinin and neuraminidase, followed by a number.
In this mouse model, we observe that when either alleles of p53 or Pten were deleted individually it did not result in any tumor formation but in combination several different subtypes of LPS were formed.
Studies of gene expression profiles have demonstrated that there are several breast cancer subtypes with different behaviour, different prognosis and, probably, different immunological actions.
