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This suggests that all three NLS-like motifs are required for recognition and the proper targeting of AtBPC6 to the nucleolus.
Thus TT slopes will be steep if a larger percentage of dots are required for recognition, and shallow when only a small percentage is needed.
Recent evidence has demonstrated that OBPs are required for recognition of odorants or pheromones in a number of species [ 9- 17].
The biotinylated lysine residue occurs in a conserved AMKM tetrapeptide, and a minimum of 75-80 resurroundingounding this motif are required for recognition by BirA.
The CPE binds cytoplasmic polyadenylation element binding protein (CPEB), an RNA binding protein containing two RNA recognition motifs and a zinc finger region, all of which are required for recognition of the CPE [21,30,31].
At the primary structure level, Shine-Dalgarno sequence and Kozak sequence should be added to the 5' end of the coding sequence since previous studies have shown that they are required for recognition of the AUG start codon to initiate translation in prokaryotes and eukaryotes, respectively, [ 43].
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They found that at least 4 mol% of galactosylated cholesterol derivatives was required for recognition by receptor and 6 mol% resulted in extensive ASGPR-mediated uptake in Hep G2 cell lines.
As mentioned above, TLR6 interaction with TLR2 has been reported to be required for recognition of microbial determinants such as zymosan and Lipoteichoic acid (LTA) [31], [32].
In addition, the C-terminal glycan of CPY* (previously termed the "D-glycan") is maintained in all variants because it is required for recognition by ERAD [36].
The lipid motif on P6 is required for recognition by TLR2 expressed on DCs and leads to a robust stimulation of T cells in vivo.
To investigate whether endocytosis was required for recognition of HCV, we tested several inhibitors that block the cellular uptake of particular structures, including viruses (Table 1).
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