Sentence examples for are required for binding from inspiring English sources

For XIAP, the second BIR domain and the linker region between BIR1 and BIR2 are required for binding and suppressing caspases-3 and -7, while the third BIR domain binds caspase-9.

These mutants were purified and screened for binding, yielding a map of residues that are required for binding and a complementary map of residues that are not required.

Moreover, the structurally abbreviated N- inden-5-yl)sulfoN- inden-5-yld Ki values ⩾43 N- inden-5-ylicates that N- inden-5-yl,N-aminoethyl nor the conformationally resulfonamidesnoethyl showedrm at the indene 3-position are required for binding.

In addition, a systematic mutational analysis of residues in and around the binding interface has identified a group of amino acids that are required for binding but do not have direct contact with the carbohydrate antigens, implying that these residues may be involved in the structural integrity of the receptor binding interface.

In this study, using site-directed mutagenesis, we have identified three residues on the VA387 capsid that are sterically close to the acetamide and are required for binding to A but not B antigens, indicating that the acetamide determines the binding specificity between the A and B antigens.

However, the simulations also show that for NT4-Nter, and to a lesser extent for NGF-Nter, helical conformations, which are required for binding to the Trk receptor, are present in the repertoire of structures that are intrinsically accessible to these peptides.

For example, while nine ZFs were required for binding of BORIS isoproteins to the H19 ICR, only five were required to bind the CST probe.

Hydroxylation modification is required for binding of the von Hippel-Lindau (VHL) protein, which targets HIF-1α and HIF-2α for ubiquitination and proteasomal degradation15.

Zhang H., Kozlov G., Li X., Wu H., Gulerez I. & Gehring K. "PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3".

The full PB1-PB2 cassette is required for binding the centriolar protein Asterless as well as robust centriole targeting.

We conclude that the RING and C2HC ZnF form a functional unit that is required for binding to the E2. Figure 1: RNF114, RNF114 and the mutants used in this study.