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miRNAs are reported to regulate a wide range of biological processes including cell cycle regulation, proliferation and differentiation as well as development, immune response, carcinogenesis and various metabolic processes [ 17- 19].
As no genes in this family are reported to regulate pollen tube growth, we used an RNAi technique to down-regulate NtGNL1 expression and confirmed that NtGNL1 plays a critical role in pollen tube growth and orientation, and it likely functions via regulating post-Golgi trafficking.
Several molecules are reported to regulate the modification of c-MYC, including GSK3, ERK and SIRT1.
PI3K, AKT, and ERK pathways are reported to regulate expression of miR-210 and VEGF.
Furthermore, similar to the Il2 gene [ 47], AP-1 and NF-κB are reported to regulate Slfn2 expression [ 48].
They are reported to regulate more than 50% of all protein-coding genes in mammalian cells [ 31, 32].
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In Drosophila, PcG complexes have been reported to regulate the expression of several cell-cycle regulators.
Selective nuclear receptor modulators have been reported to regulate ERS to control cardiovascular diseases.
Calcium has been reported to regulate placental progesterone secretion in cattle.
Lung macrophages have been reported to regulate both progression and remission of bleomycin-induced diffuse PF.
HIF1α has been reported to regulate Vegf gene expression by binding to the promoter region in many types of cells28,29.
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