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Similarly, two land plant SBP-box genes, PpSBP2 and AtSPL7, are reported to recognize a GTAC motif of CuREs and regulate nutritional copper signals [ 8, 9].
Several groups have developed 'anti-oligomer' or 'anti-amyloid' antibodies that are reported to recognize oligomers but not fibrils [ 43- 46].
While CRs recognize both avirulent and virulent strains of Mtb, MRs are reported to recognize only virulent strains [ 70], indicating that this path of entry is particularly useful for pathogenesis of virulent Mtb.
As many GntR regulators are reported to recognize palindromes and also exhibit nucleotide recognition preferences among the same subfamily [ 5], we utilised these clues to scan the upstream sequences.
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Up to now, many cytosolic DNA sensors have been reported to recognize intracellular pathogenic DNAs (Fig. 1).
C. cellulolyticum was reported to recognize cellulose availability with a carbon catabolite repression mechanism and xylan availability with a two-component system (TCS) (Celik et al. 2013; Xu et al. 2013).
For example, C. thermocellum was reported to recognize the availability of cellulose through the coordinated action of sigma and anti-sigma factors with cellulose binding domains (Nataf et al. 2010).
More recently, the endogenous AARS has been reported to recognize the close structural analogs of its cognate amino acid and helps in the in vitro and in vivo incorporation of analogs into recombinant proteins.
Human TLRs have been reported to recognize mycobacterial antigens and initiate an immune response.
Besides pathogen-associated molecular patterns (PAMPs), TLR4 has been reported to recognize also damage (host -associated molecular patterns (DAMPs) [8].
A monoclonal antibody 2E12 has been reported to recognize a subset of apoptotic cells in culture [5], [6].
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