The Delay-type operons are commonly involved in carbon metabolism and are regulated by multiple regulators and are regulated via multiple promoters, whereas, the Basic-type operons are more diverse, both in the functions they perform, as well as, in the number of regulators that control them.
These results may indicate that the expression of the 4 genes are regulated by multiple factor, the miRNA regulation may not be the major force.
These findings indicate that the PcG/TrxG targets are regulated by multiple positive and negative regulators that facilitate the establishment and removal of PcG repression.
These pleiotropic effects are regulated by multiple layers of non-genetic regulation, including epigenetic silencing and post-transcriptional regulation by post-translational modifications (PTM) and non-coding RNAs [ 7].
The transcriptional activities of ChREBP are regulated by multiple PTMs, including phosphorylation, O-GlcNAcylation, and acetylation (Guinez et al., 2011; Filhoulaud et al., 2013).
EV formation and release are regulated by multiple factors, while either endogenous or exogenous factors can change the number, content and type of EVs, thereby substantially altering their activities.
