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Groups of genes may be regulated autonomously by organising into chromatin domains, which are maintained independently from their surroundings and demarked by dynamic chromatin boundaries.
DOI: http://dx.doi.org/10.7554/eLife.03626.012 10.7554/eLiFigure26 figuregure 6—figure supplement 2. Pvr expression is regulated autonomously by bip1, Nup98, and RpS8 within the lymph gland.
These defects are regulated non-cell autonomously by steroid-hormones produced in ring glands (RG), a major endocrine organ in insects.
Although this would suggest that phyB can act cell autonomously to regulate phyB-dependent responses, mesophyll-specific expression was found to be sufficient to suppress flowering, indicating that some phyB responses are regulated non-cell autonomously [ 15].
Businesses are regulated.
As germline differentiation can be regulated cell autonomously or cell non-autonomously, we decided to test what goes awry in the GSC niche community when the ecdysone pathway is perturbed.
To examine which genes would be regulated cell autonomously by the light pulses, we also examined the effect of light exposure on cells of a zebrafish tissue culture cell line (PAC2 [16]).
To understand whether this reduction in inhibitory input was regulated cell autonomously or depended on changes in neuronal activity at the network level, we also analyzed inhibitory synaptic input in sparse TrkB.T1-expressing neurons.
Interestingly, sod-3 expression was not rescued in CY262 or CY251 animals, suggesting this target is regulated cell-autonomously and is not under endocrine control.
The goal of this analysis was to identify age-1 target genes that could be regulated non-autonomously by the age-1 pathway.
The goal of this study was to identify potential endocrine targets of age-1 activity that could be regulated non-autonomously from the nervous system and/or the intestine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com